Dissolution Testers

PharmaTest manufacturer offers a great range of Dissolutions Testers with a big variety of accessories so that any pharmaceutical laboratory may find an appropriate combination. All the apparatus are fully compliant to the valid USP 711/724 EP 2.9.3/4 methods and many international Pharmacopoeias.

The main features of PharmaTest Dissolution Testers are the following:

  • Vessel arrangement in two rows: 3+3, 4+4, 4+3 or 6+6 (with 2 additional unstirred) vessels
  • Vessel arrangement in one row: 6+2 vessels
  • Dissolution vessel volume: 0.250, 1, 2 and 4 liter clear or amber vessels are available
  • Staggered stirrer start or simultaneous stirrer start
  • Manual flip back head design (low head) or automated lift drive design (high head)
  • Manual, Semi-Manual or Fully-Manual Dissolution testing with or without In Situ photometric measurement with fiber optics technology

Manual Dissolution Testers

A typical tablet dissolution instrument includes at least 6 testing stations, 6 stirrers, a heating device to heat the dissolution media to a constant temperature and a speed control usually adjustable within a range of 20 to 200rpm.All of the instruments presented here are ready to be upgraded to a semi or fully automated system.

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Semi-Automated Dissolution Testers

The offline semi-automated Dissolution testing systems include a dissolution bath, a pump and a fraction collector which will collect the sampled dissolution media. The DSR systems can offer online dilution in addition to the sampling. Automated refilling of the collected media back into the testing vessels is possible for both the DFC and DSR systems.

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Fully Automated Dissolution Testers

Fully automated dissolution testing in this case means sampling, measuring, and result calculation are automated. The user adds the samples when prompted to do so by the system and takes care of filling and cleaning of the vessels.

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In Situ Dissolution Testers

In Situ Dissolution using Fibre Optic Probes directly inside the dissolution vessels is probably the most interesting development to happen in the dissolution technology regime for some time. There is therefore a very substantial cost and time saving which can easily be offset against the investment cost of the instrument itself. Then there is the greater sample throughput available with these types of systems.

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